Job Description

Life Science Research Professional 1 Xiao Lab (Onsite Work Agreement)

The Xiao Laboratory is a part of the Stanford Biochemistry and Stanford Cancer Institute (SCI). We are a chemical systems biology group focused on developing creative mass spectrometry (MS)-based strategies, combined with data science, to understand mechanisms of metabolic regulation over protein function in health and disease. We aim to use this as a basis to develop translational therapeutics for aging, metabolic disease, and cancer. SCI is one of an elite number of National Cancer Institute-Designated Comprehensive Cancer Centers in the country, and is a prominent, dynamic, growing and complex Institute within the Stanford University School of Medicine. The SCI actively works to build synergies and collaborations among faculty with cancer-relevant expertise from four Schools and over 30 departments across Stanford University. Given the SCI's mission, breadth, and depth, it employs over 325 staff members in a fast-paced, team-oriented, and forward-thinking environment with tremendous opportunities for personal and professional growth. You will be working with an unparalleled leading-edge community of faculty and staff who work on both basic science and clinical/translational investigations, and who are fundamentally changing the world of biomedical science and health care.

We are seeking a Life Science Research Professional 1 to perform experiments and data analysis, to contribute to publications, and to support activities in a newly-established group at Stanford. The successful candidate will perform molecular biology experiments involving genetic and pharmacological interventions in cells, as well as functional assays. The candidate will also have the opportunity to perform animal experiments, proteomics, metabolomics, and computational analyses that interface with ongoing biology efforts in the laboratory. The LSRP1 will be able to directly work with the principal investigator and other members of the lab in a collaborative environment. We are seeking candidates with excellent organizational and communication skills. Our staff embrace challenges with a high degree of professionalism, initiative and flexibility. The candidate will be conversant in the goals, mission and priorities of the Institute.

Duties include:

• Plan and perform experiments in support of research projects in lab and/or field based on knowledge of scientific theory. Interpret and perform basic analyses of results.
• Review literature on an ongoing basis to remain current with new procedures and related research.
• Offer suggestions regarding modifications to procedures and protocols in collaboration with graduate and post-doctoral individuals.
• Maintain detailed records of experiments and outcomes.
• Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
• Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
• Help orient and train new staff or students.
• Onsite Work Agreement.

Desired qualifications:

• Expertise in organic or medicinal chemistry.
• Expertise in bioinformatics and machine learning.
• Outstanding mammalian cell culture techniques.
• Experience in basic cellular and molecular biology techniques including, but not limited to, PCR, protein/DNA/RNA extraction and gel electrophoresis, bacterial transformation, imaging, cloning, gene-editing (such as CRISPR), small and large scale plasmid purification, sequencing, transfection by electroporation, transduction of viral supernatants into cell lines, and using standard software (such as Image J, BioRad, SnapGene, etc) to facilitate biological experiments.

Experience in these following areas below is a big plus:

• Experience in mass spectrometry-based proteomics and metabolomics.
• Experience working with mice and performing animal physiology experiments.
• Experience in the field of molecular metabolism.

Education & experience (required):

Bachelor's degree in related scientific field.

Knowledge, skills and abilities (required):

• General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
• Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
• Ability to maintain detailed records of experiments and outcomes.
• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
• Ability to work under deadlines with general guidance.
• Excellent organizational skills and demonstrated ability to accurately complete detailed work.

Physical requirements*:

• Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
• Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
• Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
• Must have correctible vision to perform duties of the job.
• Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
• Ability to lift heavy objects weighing up to 50 pounds.
• Ability to work in a dusty, dirty, and odorous environment.
• Position may require repetitive motion.

Working conditions:

• May require working in close proximity to blood borne pathogens.
• May require work in an environment where animals are used for teaching and research.
• Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
• Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
• May require extended or unusual work hours based on research requirements and business needs.

Work standards:

• Interpersonal skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
• Promote culture of safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.

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